Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib).

Role of Src tyrosine kinases in experimental pulmonary hypertension.

OBJECTIVE Pulmonary arterial hypertension is a progressive pulmonary vascular disorder with high morbidity and mortality. Compelling evidence suggests that receptor tyrosine kinases, such as platelet-derived growth factor (PDGF) are closely involved in the pathogenesis of pulmonary arterial hypertension. We investigated the effects of 2 novel PDGF inhibitors, nilotinib/AMN107 (Abl kinases/PDGF ...

Tyrosine Kinases in experimental Pulmonary Hypertension

P ulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disorder with high morbidity and mortality. 1 Current therapeutic approaches for the treatment of PAH mainly provide symptomatic relief, as well as some improvement in prognosis. Pathological changes observed in vascular remodeling include endothelial injury, proliferation, and migration of pulmonary arterial smooth musc...

New assignments for multitasking signal transduction inhibitors.

An article presented in this issue of Molecular Pharmacology (p. 1527) provides an intriguing example of how tyrosine kinase inhibitors can be put to many uses. In this article, the action of dasatinib (BMS-354825) is contrasted with that of imatinib, a kinase inhibitor that is currently being used to treat chronic myelogenous leukemia and other disorders. Both pharmacologic inhibitors target s...

Author's response to reviews Title: Molecular Mechanisms of Action and Potential Biomarkers of Growth Inhibition of Dasatinib (BMS-354825) On Hepatocellular Carcinoma Cells Authors:

Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562.

We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significan...